Hyaluronic acid

Hyaluronic acid is a chemical compound naturally found in the human body – mainly in the skin (primarily in the stratum spinosum), but also in the synovium, the walls of blood vessels and the vitreous body of the eye. It is one of the components of the intercellular matrix. Its presence in the skin is due to its smoothness, firmness and elasticity. Naturally, it is in the form of a sodium salt – sodium hyaluronate.

As we age, the amount of hyaluronic acid in the human body decreases. The result is much less elasticity in the skin, wrinkles and difficulty in maintaining hydration. Hyaluronic acid completely disappears from our body around 80. year of age. Of course, this can happen faster through factors such as smoking, hormonal disorders or air pollution.

Properties of hyaluronic acid

The most important feature of hyaluronic acid is its hygroscopic properties (it binds molecules – absorbs water). One molecule of hyaluronic acid can bind about 250 molecules of water. This has made hyaluronic acid a popular ingredient in moisturizing, protective and anti-aging creams.

Form of hyaluronic acid


In cosmetics we meet hyaluronic acid in various structural forms:

  • Short-molecular – moisturizes long-lasting as it penetrates the deeper layers of the skin.
  • Medium-molecular – has a strong moisturizing effect (only in the stratum corneum). It works immediately, but briefly. It gives the impression of smoothing and firming, which unfortunately quickly disappears.
  • High molecular weight – protects the skin from water evaporation due to the thin layer it forms on the skin.

In some cosmetic products, one can find hyaluronic acid encapsulated in liposomes to facilitate penetration into the deeper layers of the epidermis.

Aesthetic medicine

In aesthetic medicine, hyaluronic acid is used for wrinkle filling and lip augmentation and shaping. It comes in various forms of cross-linking:

  • In mesotherapy cocktails, it is in a non-cross-linked form,
  • cross-linked hyaluronic acid becomes a filler.

Hyaluronic acid filler is in the form of a powder obtained by biofermentation, purification and drying. The surgeon performing the procedure adds water, resulting in a filler in the form of a clear gel ready for application.

In addition to lip contouring, this filler is also used to restore tissue defects or smooth nasolabial furrows.


The first use of hyaluronic acid was in the 1940s. XX age. It was used by veterinarians for racehorse injuries. Since the 1960s. it is also used in ophthalmology – in operations for retinal detachment, and later also in lens implantation.


The use of hyaluronic acid creams is necessary to maintain healthy, beautiful skin.

NMF xpress cream – a deeply moisturizing cream for use at any time of day or year. It uses liposomes to transport glacial water deep into the skin, prolonging the action and effect of hydration.

Novo – night cream with 8% glycolic acid. It exfoliates dead skin cells, leaving the skin visibly refreshed and smooth.

City eye cream – eye cream is the perfect complement to the care. The skin in this area is delicate and requires a different, better adapted type of care to help “deal” with bruising, “bags under the eyes” and wrinkles.

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